Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy

Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy

Cancer patients by immune checkpoint therapy have achieved long-term remission, with no recurrence of clinical symptoms of cancer for many years. Nevertheless, more than half of cancer patients are not responsive to this therapy due to immune exhaustion. Here, we report a novel gene engineered exoso...

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Bibliographic Details
Main Authors: Peishan Li, Ying Xie, Jinling Wang, Chunjie Bao, Jialun Duan, Yixuan Liu, Qian Luo, Jiarui Xu, Yuxin Ren, Min Jiang, Jianwei Li, Haitao Guo, Huihui Zhao, Guiling Wang, Yanqin Liang, Wanliang Lu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-04-01
Series:Bioactive Materials
Subjects:
Gene engineered exosomes
T cell exhaustion
PD1/PDL1
Imiquimod
Cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000082

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http://www.sciencedirect.com/science/article/pii/S2452199X24000082

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