Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis

Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis

Abstract Background No effective therapies for pulmonary fibrosis (PF) exist because of the unclear molecular pathogenesis and the lack of effective therapeutic targets. Zinc finger protein 451 (ZNF451), a transcriptional regulator, plays crucial roles in the pathogenesis of several diseases. Howeve...

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Bibliographic Details
Main Authors: Hong Peng, Yu Zhang, Jiali Min, Yuexin Tan, Shanshan Liu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Respiratory Research
Subjects:
Pulmonary fibrosis
Fibroblast activation
ZNF451
PDGFB
Online Access:https://doi.org/10.1186/s12931-024-02781-7

Internet

https://doi.org/10.1186/s12931-024-02781-7

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