Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus

Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus

The small GTPase Ran is the main regulator of the nucleo-cytoplasmic import and export through the nuclear pore complex. It functions as a molecular switch cycling between the GDP-bound inactive and GTP-bound active state. It consists of a globular (G) domain and a C-terminal region, which is bound...

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Bibliographic Details
Main Authors: Janka Czigleczki, Pedro Tulio de Resende Lara, Balint Dudas, Hyunbum Jang, David Perahia, Ruth Nussinov, Erika Balog
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
Ran
small GTPase
conformational switch
C-terminus
conformational search
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1111574/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1111574/full

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