A zebrafish model of manganism reveals reversible and treatable symptoms that are independent of neurotoxicity

Manganese (manganese ion; referred to as Mn) is essential for neuronal function, yet it is toxic at high concentrations. Environmental and occupational exposure to high concentrations of Mn causes manganism, a well-defined movement disorder in humans, with symptoms resembling Parkinson’s disease (PD...

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Bibliographic Details
Main Authors: Subha Bakthavatsalam, Shreya Das Sharma, Mahendra Sonawane, Vatsala Thirumalai, Ankona Datta
Format: Article
Language:English
Published: The Company of Biologists 2014-11-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/7/11/1239