Positron emission tomography imaging of the P2X7 receptor with a novel tracer, [18F]GSK1482160, in a transgenic mouse model of Alzheimer's disease and healthy non‐human primates

Positron emission tomography imaging of the P2X7 receptor with a novel tracer, [18F]GSK1482160, in a transgenic mouse model of Alzheimer's disease and healthy non‐human primates

Abstract This study aimed to evaluate [18F]GSK1482160 Positron emission tomography imaging for targeting P2X7R, a biomarker for neuroinflammation. Studies of acute neuroinflammation in rodents and transgenic mice with Alzheimer's disease (AD), as well as wild‐type (WT) controls, were conducted...

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Bibliographic Details
Main Authors: Yifan Qiu, Lei Bi, Guolong Huang, Zhijun Li, Huiyi Wei, Guocong Li, Junjie Wei, Kai Liao, Min Yang, Peizhen Ye, Yongshan Liu, Xianxian Zhao, Yuyi Hou, Yanfang Shen, Renwei Zhou, Tuoen Liu, Henry Hoi Yee Tong, Lu Wang, Hongjun Jin
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Brain-X
Subjects:
[18F]GSK1482160
Alzheimer's disease
neuroinflammation
P2X7R
positron emission tomography
Online Access:https://doi.org/10.1002/brx2.55

Internet

https://doi.org/10.1002/brx2.55

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