The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
Abstract In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-02-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-023-02723-y |
| _version_ | 1811165810919473152 |
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| author | Yuxiang Xu Yongjie Li Changqing Wang Tingting Han Haixuan Liu Lin Sun Jun Hong Makoto Hashimoto Jianshe Wei |
| author_facet | Yuxiang Xu Yongjie Li Changqing Wang Tingting Han Haixuan Liu Lin Sun Jun Hong Makoto Hashimoto Jianshe Wei |
| author_sort | Yuxiang Xu |
| collection | DOAJ |
| description | Abstract In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the loss of dopaminergic neurons. So far, we have mainly focused on the role of the specific class of immune cells in PD while neglecting the impact of interactions among immune cells on the disease. Therefore, this review demonstrates the reciprocal interplays between microglia and T cells and the associated subpopulations through cytokine and chemokine production that impair and/or protect the pathological process of PD. Furthermore, potential targets and models of PD neuroinflammation are highlighted to provide the new ideas/directions for future research. |
| first_indexed | 2024-04-10T15:42:40Z |
| format | Article |
| id | doaj.art-fb318a636f754309a48bba5b4d49019a |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-10T15:42:40Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-fb318a636f754309a48bba5b4d49019a2023-02-12T12:18:26ZengBMCJournal of Neuroinflammation1742-20942023-02-0120111410.1186/s12974-023-02723-yThe reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged swordYuxiang Xu0Yongjie Li1Changqing Wang2Tingting Han3Haixuan Liu4Lin Sun5Jun Hong6Makoto Hashimoto7Jianshe Wei8Institute for Brain Sciences Research, School of Life Sciences, Henan UniversityDepartment of Rehabilitation Medicine, Beijing Jishuitan Hospital Guizhou Hospital, Guizhou Provincial Orthopedics HospitalInstitute for Brain Sciences Research, School of Life Sciences, Henan UniversityInstitute for Brain Sciences Research, School of Life Sciences, Henan UniversityInstitute for Brain Sciences Research, School of Life Sciences, Henan UniversityHenan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan UniversityInstitute for Brain Sciences Research, School of Life Sciences, Henan UniversityTokyo Metropolitan Institute of Medical ScienceInstitute for Brain Sciences Research, School of Life Sciences, Henan UniversityAbstract In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the loss of dopaminergic neurons. So far, we have mainly focused on the role of the specific class of immune cells in PD while neglecting the impact of interactions among immune cells on the disease. Therefore, this review demonstrates the reciprocal interplays between microglia and T cells and the associated subpopulations through cytokine and chemokine production that impair and/or protect the pathological process of PD. Furthermore, potential targets and models of PD neuroinflammation are highlighted to provide the new ideas/directions for future research.https://doi.org/10.1186/s12974-023-02723-yMicrogliaT cellCell–cell interactionsChemokinesParkinson’s diseaseCytokines |
| spellingShingle | Yuxiang Xu Yongjie Li Changqing Wang Tingting Han Haixuan Liu Lin Sun Jun Hong Makoto Hashimoto Jianshe Wei The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword Journal of Neuroinflammation Microglia T cell Cell–cell interactions Chemokines Parkinson’s disease Cytokines |
| title | The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword |
| title_full | The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword |
| title_fullStr | The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword |
| title_full_unstemmed | The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword |
| title_short | The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword |
| title_sort | reciprocal interactions between microglia and t cells in parkinson s disease a double edged sword |
| topic | Microglia T cell Cell–cell interactions Chemokines Parkinson’s disease Cytokines |
| url | https://doi.org/10.1186/s12974-023-02723-y |
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