Progressive Sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes

Progressive Sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes

Bacterial exposure to antibiotic concentrations below the minimum inhibitory concentration (MIC) may result in a selection window allowing for the rapid evolution of resistance. These sub-MIC concentrations are commonly found in soils and water supplies in the greater environment. This study aimed t...

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Bibliographic Details
Main Authors: Jasmine R. Anderson, Nghi B. Lam, Jazmyne L. Jackson, Sean M. Dorenkott, Taylor Ticer, Emir Maldosevic, Amanda Velez, Megan R. Camden, Terri N. Ellis
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antibiotics
Subjects:
<i>Klebsiella pneumoniae</i>
antibiotic resistance
selection window
capsule
beta-lactams
Online Access:https://www.mdpi.com/2079-6382/12/5/887

Internet

https://www.mdpi.com/2079-6382/12/5/887

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