Mutation of GGMP Repeat Segments of <i>Plasmodium falciparum</i> Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding

Mutation of GGMP Repeat Segments of <i>Plasmodium falciparum</i> Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding

Parasitic organisms especially those of the Apicomplexan phylum, harbour a cytosol localised canonical Hsp70 chaperone. One of the defining features of this protein is the presence of GGMP repeat residues sandwiched between α-helical lid and C-terminal EEVD motif. The role of the GGMP repeats of Hsp...

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Bibliographic Details
Main Authors: Stanley Makumire, Tendamudzimu Harmfree Dongola, Graham Chakafana, Lufuno Tshikonwane, Cecilia Tshikani Chauke, Tarushai Maharaj, Tawanda Zininga, Addmore Shonhai
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
malaria
<i>Plasmodium falciparum</i>
chaperone
GGMP repeats
Hsp70
Hop
Online Access:https://www.mdpi.com/1422-0067/22/4/2226

Internet

https://www.mdpi.com/1422-0067/22/4/2226

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