Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse.

Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse.

Mice over-expressing the alpha(1)_subunit (pore) of the L-type Ca2+ channel (alpha(1C)TG) by 4 months (mo) of age exhibit an enlarged heart, hypertrophied myocytes, increased Ca2+ current and Ca2+ transient amplitude, but a normal SR Ca2+ load. With advancing age (8-11 mo), some mice demonstrate adv...

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Bibliographic Details
Main Authors: Su Wang, Bruce Ziman, Ilona Bodi, Marta Rubio, Ying-Ying Zhou, Karen D'Souza, Nanette H Bishopric, Arnold Schwartz, Edward G Lakatta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2607013?pdf=render

Internet

http://europepmc.org/articles/PMC2607013?pdf=render

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