Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma

Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma

The tumor microenvironment (TME) plays a pivotal role in establishing malignancy, and it is associated with high glycolytic metabolism and lactate release through monocarboxylate transporters (MCTs). Several lines of evidence suggest that lactate also serves as a signaling molecule through its recep...

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Bibliographic Details
Main Authors: Lucia Longhitano, Nunzio Vicario, Daniele Tibullo, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Marta Baghini, Michelino Di Rosa, Rosalba Parenti, Antonio Giordano, Maria Caterina Mione, Giovanni Li Volti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
lactate
glioblastoma
MCT1 (SLC16A1)
HCAR1
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.871798/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.871798/full

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