Computable structured aptamer for targeted treatment of ovarian cancer

Computable structured aptamer for targeted treatment of ovarian cancer

Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin. In addition, to superior serum stability and drug lo...

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Bibliographic Details
Main Authors: Luoshan Ruan, Liting Han, Xin Li, Xin Chen, Gege Sun, Xinyu Wang, Yan Luo, Chuanqi Gu, Xiaolong Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Genetics
Subjects:
nucleolin
AS1411 aptamer
DNA tile
doxorubicin
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1170260/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1170260/full

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