Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)

Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)

5,6-Dimethylxanthenone-4-acetic acid (DMXAA) acts through tumor vascular disruption and cytokine production and is the first of its class to enter phase 3 trials. We characterized leukocytes and cytokines in murine Colon 38 tumors before and after DMXAA treatment. Tumor mass declined 50% 24 hours af...

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Bibliographic Details
Main Authors: Liang-Chuan S. Wang, Lotte Thomsen, Rachel Sutherland, Charu B. Reddy, Sofian M. Tijono, Chun-Jen J. Chen, Catherine E. Angel, P. Rod Dunbar, Lai-Ming Ching
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609801358

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http://www.sciencedirect.com/science/article/pii/S1476558609801358

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