The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene

The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene

Background: Mutations in the glucocerebrosidase (GBA1) and leucine-rich repeat kinase 2 (LRRK2) genes, encoding lysosomal enzyme glucocerebrosidase (GCase) and leucine-rich repeat kinase 2 (LRRK2), respectively, are the most common related to Parkinson’s disease (PD). Recent data suggest a possible...

Full description

Bibliographic Details
Main Authors: Tatiana S. Usenko, Alla Timofeeva, Mariia Beletskaia, Katerina Basharova, Galina Baydakova, Anastasia Bezrukova, Maria Grunina, Anton Emelyanov, Irina Miliukhina, Ekaterina Zakharova, Sofya Pchelina
Format: Article
Language:English
Published: IMR Press 2024-01-01
Series:Journal of Integrative Neuroscience
Subjects:
parkinson's disease
gba1
lrrk2
lysosomal enzyme activity
lysosphingolipids
Online Access:https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301016

Internet

https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301016

Similar Items