Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

Gout is caused by elevated serum urate leading to the deposition of monosodium urate (MSU) crystals that can trigger episodes of acute inflammation. Humans are sensitive to developing gout because they lack a functional urate-metabolizing enzyme called uricase/urate oxidase (encoded by the <i>...

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Bibliographic Details
Main Authors: Tanja Linnerz, Yih Jian Sung, Leah Rolland, Jonathan W. Astin, Nicola Dalbeth, Christopher J. Hall
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
gout
zebrafish
uricase
urate
hyperuricemia
inflammation
Online Access:https://www.mdpi.com/2073-4425/13/12/2179

Internet

https://www.mdpi.com/2073-4425/13/12/2179

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