Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. Using a tamoxifen-inducible CalcaCreER transgenic mouse, here we identified a distinct population of CGRP-expressing e...

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Bibliographic Details
Main Authors: Line S Löken, Joao M Braz, Alexander Etlin, Mahsa Sadeghi, Mollie Bernstein, Madison Jewell, Marilyn Steyert, Julia Kuhn, Katherine Hamel, Ida J Llewellyn-Smith, Allan Basbaum
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
pain
touch
CGRP
interneurons
spinal cord
mechanical sensitivity
Online Access:https://elifesciences.org/articles/59751

Internet

https://elifesciences.org/articles/59751

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