The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

Spleen tyrosine kinase (SYK) is an enigmatic protein tyrosine kinase, and involved in signal transduction related with lots of cellular processes. It’s highly expressed in the cells of hematopoietic origin and acts as an important therapeutic target in the treatment of autoimmune diseases and allerg...

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Manylion Llyfryddiaeth
Prif Awduron:	Yaping Zhao, Rongrong Liu, Miaomiao Li, Pengfei Liu
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Elsevier 2022-12-01
Cyfres:	Heliyon
Pynciau:	Spleen tyrosine kinase (SYK) Liver diseases Small molecule inhibitor Therapy target
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2405844022034181

Eitemau Tebyg

The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis
gan: Eszter Káposztás, et al.
Cyhoeddwyd: (2023-12-01)

Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib
gan: Nichola Cooper, et al.
Cyhoeddwyd: (2023-01-01)

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets
gan: Pankaj Kumar Singh, et al.
Cyhoeddwyd: (2023-12-01)

Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway
gan: Chenglong Zhou, et al.
Cyhoeddwyd: (2024-12-01)

Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence [version 3; peer review: 2 approved]
gan: Carl Laflamme, et al.
Cyhoeddwyd: (2024-06-01)

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice
gan: Dániel Csete, et al.
Cyhoeddwyd: (2019-04-01)

Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases
gan: Mohan Li, et al.
Cyhoeddwyd: (2023-05-01)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
gan: Ryunosuke Muro, et al.
Cyhoeddwyd: (2023-01-01)

Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
gan: Christopher W. Pohlmeyer, et al.
Cyhoeddwyd: (2021-03-01)

Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase
gan: Bright Obeng, et al.
Cyhoeddwyd: (2024-12-01)

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
gan: Kata P. Szilveszter, et al.
Cyhoeddwyd: (2019-08-01)

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis
gan: Mariano Prado Acosta, et al.
Cyhoeddwyd: (2021-03-01)

A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells
gan: Hyang‑Hee Seo, et al.

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to <italic toggle="yes">Candida</italic> Species
gan: Paige E. Negoro, et al.
Cyhoeddwyd: (2020-06-01)

Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
gan: Yaqi Zhou, et al.
Cyhoeddwyd: (2023-07-01)

CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease
gan: Wenbin Gong, et al.
Cyhoeddwyd: (2021-02-01)

Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma
gan: Qian Liu, et al.
Cyhoeddwyd: (2022-05-01)

Systematic analysis of spleen tyrosine kinase expression and its clinical outcomes in various cancers
gan: Akram I Alwithenani, et al.
Cyhoeddwyd: (2020-01-01)

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets
gan: Carol Dangelmaier, et al.
Cyhoeddwyd: (2024-12-01)

The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients
gan: Jing Wang, et al.
Cyhoeddwyd: (2023-02-01)

Expression of variant isoforms of the tyrosine kinase SYK differentially regulates cervical cancer progression through PI3K/AKT pathway
gan: Bingjie Lin, et al.
Cyhoeddwyd: (2024-11-01)

Three Novel Players: PTK2B, SYK, and TNFRSF21 Were Identified to Be Involved in the Regulation of Bovine Mastitis Susceptibility via GWAS and Post-transcriptional Analysis
gan: Fan Yang, et al.
Cyhoeddwyd: (2019-08-01)

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants
gan: Jacob L. Capener, et al.
Cyhoeddwyd: (2024-07-01)

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice
gan: Maki Kitai, et al.
Cyhoeddwyd: (2017-05-01)

Mechanisms of acquired resistance to tyrosine kinase inhibitors
gan: Yi-fan Chen, et al.
Cyhoeddwyd: (2011-12-01)

Tyrosine kinase targeting: A potential therapeutic strategy for diabetes
gan: Mohammad Althubiti
Cyhoeddwyd: (2022-01-01)

Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions
gan: Alex Hopke, et al.
Cyhoeddwyd: (2025-01-01)

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease
gan: Soumitra Ghosh, et al.
Cyhoeddwyd: (2015-11-01)

Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages
gan: Zeina Dagher, et al.
Cyhoeddwyd: (2018-05-01)

Aberrant RON and MET Co-overexpression as Novel Prognostic Biomarkers of Shortened Patient Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Pancreatic Cancer
gan: Chen-Yu Hu, et al.
Cyhoeddwyd: (2019-12-01)

Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies
gan: Xuejin Ou, et al.
Cyhoeddwyd: (2024-09-01)

Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization
gan: Halil Ibrahim Onder, et al.
Cyhoeddwyd: (2014-04-01)

Receptor Tyrosine Kinase Signaling Involves <i>Echinococcus</i>–Host Intercommunication: A Potential Therapeutic Target in Hepatic Echinococcosis
gan: Haijun Gao, et al.
Cyhoeddwyd: (2024-08-01)

Advances in studies of tyrosine kinase inhibitors and their acquired resistance
gan: Qinlian Jiao, et al.
Cyhoeddwyd: (2018-02-01)

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
gan: Sareshma Sudhesh Dev, et al.
Cyhoeddwyd: (2021-11-01)

Exploring receptor tyrosine kinases-inhibitors in Cancer treatments
gan: D. Samuel Metibemu, et al.
Cyhoeddwyd: (2019-12-01)

Recent developments in receptor tyrosine kinases targeted anticancer therapy
gan: Samir H. Raval, et al.
Cyhoeddwyd: (2016-01-01)

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
gan: Hadas Smadar, et al.
Cyhoeddwyd: (2012-07-01)

Characterization of acquired receptor tyrosine–kinase fusions as mechanisms of resistance to EGFR tyrosine–kinase inhibitors
gan: Xu H, et al.
Cyhoeddwyd: (2019-07-01)

Therapeutic potential of tyrosine-protein kinase MET in osteosarcoma
gan: Ming Zeng, et al.
Cyhoeddwyd: (2024-03-01)