The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

Spleen tyrosine kinase (SYK) is an enigmatic protein tyrosine kinase, and involved in signal transduction related with lots of cellular processes. It’s highly expressed in the cells of hematopoietic origin and acts as an important therapeutic target in the treatment of autoimmune diseases and allerg...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Yaping Zhao, Rongrong Liu, Miaomiao Li, Pengfei Liu
Format:	Article
Sprog:	English
Udgivet:	Elsevier 2022-12-01
Serier:	Heliyon
Fag:	Spleen tyrosine kinase (SYK) Liver diseases Small molecule inhibitor Therapy target
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2405844022034181

Lignende værker

The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis
af: Eszter Káposztás, et al.
Udgivet: (2023-12-01)

Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib
af: Nichola Cooper, et al.
Udgivet: (2023-01-01)

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets
af: Pankaj Kumar Singh, et al.
Udgivet: (2023-12-01)

Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway
af: Chenglong Zhou, et al.
Udgivet: (2024-12-01)

Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence [version 3; peer review: 2 approved]
af: Carl Laflamme, et al.
Udgivet: (2024-06-01)

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice
af: Dániel Csete, et al.
Udgivet: (2019-04-01)

Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases
af: Mohan Li, et al.
Udgivet: (2023-05-01)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
af: Ryunosuke Muro, et al.
Udgivet: (2023-01-01)

Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
af: Christopher W. Pohlmeyer, et al.
Udgivet: (2021-03-01)

Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase
af: Bright Obeng, et al.
Udgivet: (2024-12-01)

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
af: Kata P. Szilveszter, et al.
Udgivet: (2019-08-01)

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis
af: Mariano Prado Acosta, et al.
Udgivet: (2021-03-01)

A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells
af: Hyang‑Hee Seo, et al.

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to <italic toggle="yes">Candida</italic> Species
af: Paige E. Negoro, et al.
Udgivet: (2020-06-01)

Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
af: Yaqi Zhou, et al.
Udgivet: (2023-07-01)

CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease
af: Wenbin Gong, et al.
Udgivet: (2021-02-01)

Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma
af: Qian Liu, et al.
Udgivet: (2022-05-01)

Systematic analysis of spleen tyrosine kinase expression and its clinical outcomes in various cancers
af: Akram I Alwithenani, et al.
Udgivet: (2020-01-01)

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets
af: Carol Dangelmaier, et al.
Udgivet: (2024-12-01)

The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients
af: Jing Wang, et al.
Udgivet: (2023-02-01)

Expression of variant isoforms of the tyrosine kinase SYK differentially regulates cervical cancer progression through PI3K/AKT pathway
af: Bingjie Lin, et al.
Udgivet: (2024-11-01)

Three Novel Players: PTK2B, SYK, and TNFRSF21 Were Identified to Be Involved in the Regulation of Bovine Mastitis Susceptibility via GWAS and Post-transcriptional Analysis
af: Fan Yang, et al.
Udgivet: (2019-08-01)

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants
af: Jacob L. Capener, et al.
Udgivet: (2024-07-01)

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice
af: Maki Kitai, et al.
Udgivet: (2017-05-01)

Mechanisms of acquired resistance to tyrosine kinase inhibitors
af: Yi-fan Chen, et al.
Udgivet: (2011-12-01)

Tyrosine kinase targeting: A potential therapeutic strategy for diabetes
af: Mohammad Althubiti
Udgivet: (2022-01-01)

Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions
af: Alex Hopke, et al.
Udgivet: (2025-01-01)

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease
af: Soumitra Ghosh, et al.
Udgivet: (2015-11-01)

Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages
af: Zeina Dagher, et al.
Udgivet: (2018-05-01)

Aberrant RON and MET Co-overexpression as Novel Prognostic Biomarkers of Shortened Patient Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Pancreatic Cancer
af: Chen-Yu Hu, et al.
Udgivet: (2019-12-01)

Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies
af: Xuejin Ou, et al.
Udgivet: (2024-09-01)

Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization
af: Halil Ibrahim Onder, et al.
Udgivet: (2014-04-01)

Receptor Tyrosine Kinase Signaling Involves <i>Echinococcus</i>–Host Intercommunication: A Potential Therapeutic Target in Hepatic Echinococcosis
af: Haijun Gao, et al.
Udgivet: (2024-08-01)

Advances in studies of tyrosine kinase inhibitors and their acquired resistance
af: Qinlian Jiao, et al.
Udgivet: (2018-02-01)

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
af: Sareshma Sudhesh Dev, et al.
Udgivet: (2021-11-01)

Exploring receptor tyrosine kinases-inhibitors in Cancer treatments
af: D. Samuel Metibemu, et al.
Udgivet: (2019-12-01)

Recent developments in receptor tyrosine kinases targeted anticancer therapy
af: Samir H. Raval, et al.
Udgivet: (2016-01-01)

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
af: Hadas Smadar, et al.
Udgivet: (2012-07-01)

Characterization of acquired receptor tyrosine–kinase fusions as mechanisms of resistance to EGFR tyrosine–kinase inhibitors
af: Xu H, et al.
Udgivet: (2019-07-01)

Therapeutic potential of tyrosine-protein kinase MET in osteosarcoma
af: Ming Zeng, et al.
Udgivet: (2024-03-01)