The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

The spleen tyrosine kinase (SYK): A crucial therapeutic target for diverse liver diseases

Spleen tyrosine kinase (SYK) is an enigmatic protein tyrosine kinase, and involved in signal transduction related with lots of cellular processes. It’s highly expressed in the cells of hematopoietic origin and acts as an important therapeutic target in the treatment of autoimmune diseases and allerg...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Yaping Zhao, Rongrong Liu, Miaomiao Li, Pengfei Liu
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	Elsevier 2022-12-01
Σειρά:	Heliyon
Θέματα:	Spleen tyrosine kinase (SYK) Liver diseases Small molecule inhibitor Therapy target
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2405844022034181

Παρόμοια τεκμήρια

The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis
ανά: Eszter Káposztás, κ.ά.
Έκδοση: (2023-12-01)

Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib
ανά: Nichola Cooper, κ.ά.
Έκδοση: (2023-01-01)

Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets
ανά: Pankaj Kumar Singh, κ.ά.
Έκδοση: (2023-12-01)

Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway
ανά: Chenglong Zhou, κ.ά.
Έκδοση: (2024-12-01)

Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence [version 3; peer review: 2 approved]
ανά: Carl Laflamme, κ.ά.
Έκδοση: (2024-06-01)

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice
ανά: Dániel Csete, κ.ά.
Έκδοση: (2019-04-01)

Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases
ανά: Mohan Li, κ.ά.
Έκδοση: (2023-05-01)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
ανά: Ryunosuke Muro, κ.ά.
Έκδοση: (2023-01-01)

Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
ανά: Christopher W. Pohlmeyer, κ.ά.
Έκδοση: (2021-03-01)

Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase
ανά: Bright Obeng, κ.ά.
Έκδοση: (2024-12-01)

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
ανά: Kata P. Szilveszter, κ.ά.
Έκδοση: (2019-08-01)

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis
ανά: Mariano Prado Acosta, κ.ά.
Έκδοση: (2021-03-01)

A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells
ανά: Hyang‑Hee Seo, κ.ά.

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to <italic toggle="yes">Candida</italic> Species
ανά: Paige E. Negoro, κ.ά.
Έκδοση: (2020-06-01)

Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
ανά: Yaqi Zhou, κ.ά.
Έκδοση: (2023-07-01)

CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease
ανά: Wenbin Gong, κ.ά.
Έκδοση: (2021-02-01)

Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma
ανά: Qian Liu, κ.ά.
Έκδοση: (2022-05-01)

Systematic analysis of spleen tyrosine kinase expression and its clinical outcomes in various cancers
ανά: Akram I Alwithenani, κ.ά.
Έκδοση: (2020-01-01)

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets
ανά: Carol Dangelmaier, κ.ά.
Έκδοση: (2024-12-01)

The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients
ανά: Jing Wang, κ.ά.
Έκδοση: (2023-02-01)

Expression of variant isoforms of the tyrosine kinase SYK differentially regulates cervical cancer progression through PI3K/AKT pathway
ανά: Bingjie Lin, κ.ά.
Έκδοση: (2024-11-01)

Three Novel Players: PTK2B, SYK, and TNFRSF21 Were Identified to Be Involved in the Regulation of Bovine Mastitis Susceptibility via GWAS and Post-transcriptional Analysis
ανά: Fan Yang, κ.ά.
Έκδοση: (2019-08-01)

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants
ανά: Jacob L. Capener, κ.ά.
Έκδοση: (2024-07-01)

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice
ανά: Maki Kitai, κ.ά.
Έκδοση: (2017-05-01)

Mechanisms of acquired resistance to tyrosine kinase inhibitors
ανά: Yi-fan Chen, κ.ά.
Έκδοση: (2011-12-01)

Tyrosine kinase targeting: A potential therapeutic strategy for diabetes
ανά: Mohammad Althubiti
Έκδοση: (2022-01-01)

Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions
ανά: Alex Hopke, κ.ά.
Έκδοση: (2025-01-01)

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease
ανά: Soumitra Ghosh, κ.ά.
Έκδοση: (2015-11-01)

Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages
ανά: Zeina Dagher, κ.ά.
Έκδοση: (2018-05-01)

Aberrant RON and MET Co-overexpression as Novel Prognostic Biomarkers of Shortened Patient Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Pancreatic Cancer
ανά: Chen-Yu Hu, κ.ά.
Έκδοση: (2019-12-01)

Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies
ανά: Xuejin Ou, κ.ά.
Έκδοση: (2024-09-01)

Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization
ανά: Halil Ibrahim Onder, κ.ά.
Έκδοση: (2014-04-01)

Receptor Tyrosine Kinase Signaling Involves <i>Echinococcus</i>–Host Intercommunication: A Potential Therapeutic Target in Hepatic Echinococcosis
ανά: Haijun Gao, κ.ά.
Έκδοση: (2024-08-01)

Advances in studies of tyrosine kinase inhibitors and their acquired resistance
ανά: Qinlian Jiao, κ.ά.
Έκδοση: (2018-02-01)

Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
ανά: Sareshma Sudhesh Dev, κ.ά.
Έκδοση: (2021-11-01)

Exploring receptor tyrosine kinases-inhibitors in Cancer treatments
ανά: D. Samuel Metibemu, κ.ά.
Έκδοση: (2019-12-01)

Recent developments in receptor tyrosine kinases targeted anticancer therapy
ανά: Samir H. Raval, κ.ά.
Έκδοση: (2016-01-01)

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
ανά: Hadas Smadar, κ.ά.
Έκδοση: (2012-07-01)

Characterization of acquired receptor tyrosine–kinase fusions as mechanisms of resistance to EGFR tyrosine–kinase inhibitors
ανά: Xu H, κ.ά.
Έκδοση: (2019-07-01)

Therapeutic potential of tyrosine-protein kinase MET in osteosarcoma
ανά: Ming Zeng, κ.ά.
Έκδοση: (2024-03-01)