Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency

Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency

Esophageal cancer is a cancer with poor prognosis and the standard 1st line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe treatment-related toxicities due to deficienc...

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Bibliographic Details
Main Authors: Antonin Schmitt, Bernard Royer, Romain Boidot, Joseph Berthier, François Ghiringhelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
uracilemia
DPD deficiency
5-Fu (5-Fluorouracil)
esophageal cancer
therapeutic drug monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/full

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