Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency
Esophageal cancer is a cancer with poor prognosis and the standard 1st line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe treatment-related toxicities due to deficienc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/full |
| _version_ | 1827920892316876800 |
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| author | Antonin Schmitt Antonin Schmitt Bernard Royer Romain Boidot Joseph Berthier François Ghiringhelli François Ghiringhelli |
| author_facet | Antonin Schmitt Antonin Schmitt Bernard Royer Romain Boidot Joseph Berthier François Ghiringhelli François Ghiringhelli |
| author_sort | Antonin Schmitt |
| collection | DOAJ |
| description | Esophageal cancer is a cancer with poor prognosis and the standard 1st line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe treatment-related toxicities due to deficiency of dihydropyrimidine dehydrogenase (DPD). In this case report, a 74-year-old man with metastatic esophageal cancer was found to have partial DPD deficiency based on uracilemia measurements (about 90 ng/mL). Despite this, 5-FU was safely administered thanks to therapeutic drug monitoring (TDM). The case report highlights the importance of TDM in administering 5-FU to patients with partial DPD deficiency, as it allows individualized dosing and prevents severe toxicity. |
| first_indexed | 2024-03-13T04:18:17Z |
| format | Article |
| id | doaj.art-fb43c09a336148f89968870d2201a771 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T04:18:17Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fb43c09a336148f89968870d2201a7712023-06-20T22:19:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11870521187052Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiencyAntonin Schmitt0Antonin Schmitt1Bernard Royer2Romain Boidot3Joseph Berthier4François Ghiringhelli5François Ghiringhelli6Pharmacy Department, Centre Georges-François Leclerc, Dijon, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM) U1231, University of Burgundy Franche-Comté, Dijon, FrancePharmacology and Toxicology Laboratory, Besançon University Hospital, Dijon, FranceUnit of Molecular Biology, Centre Georges-François Leclerc, Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB) Unité Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 6302, Dijon, FrancePharmacology and Toxicology Laboratory, Dijon University Hospital, Dijon, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM) U1231, University of Burgundy Franche-Comté, Dijon, FranceMedical Oncology Department, Centre Georges-François Leclerc, Dijon, FranceEsophageal cancer is a cancer with poor prognosis and the standard 1st line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe treatment-related toxicities due to deficiency of dihydropyrimidine dehydrogenase (DPD). In this case report, a 74-year-old man with metastatic esophageal cancer was found to have partial DPD deficiency based on uracilemia measurements (about 90 ng/mL). Despite this, 5-FU was safely administered thanks to therapeutic drug monitoring (TDM). The case report highlights the importance of TDM in administering 5-FU to patients with partial DPD deficiency, as it allows individualized dosing and prevents severe toxicity.https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/fulluracilemiaDPD deficiency5-Fu (5-Fluorouracil)esophageal cancertherapeutic drug monitoring |
| spellingShingle | Antonin Schmitt Antonin Schmitt Bernard Royer Romain Boidot Joseph Berthier François Ghiringhelli François Ghiringhelli Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency Frontiers in Oncology uracilemia DPD deficiency 5-Fu (5-Fluorouracil) esophageal cancer therapeutic drug monitoring |
| title | Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency |
| title_full | Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency |
| title_fullStr | Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency |
| title_full_unstemmed | Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency |
| title_short | Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency |
| title_sort | case report 5 fluorouracil treatment in patient with an important partial dpd deficiency |
| topic | uracilemia DPD deficiency 5-Fu (5-Fluorouracil) esophageal cancer therapeutic drug monitoring |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/full |
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