Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system. Moreover, FHR-1, FHR-2, and FHR-5 have been proposed to be dimers, which further complicates accurate analysis. As FHRs ar...

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Bibliographic Details
Main Authors: Anna E. van Beek, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer, Martin de Boer, Karin van Leeuwen, Theo Rispens, Diana Wouters, Taco W. Kuijpers
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
innate immunity
complement factor H
factor H-related proteins
CFHR1
CFHR2
CFHR5
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01328/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01328/full

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