NeoPHOX – a structurally tunable ligand system for asymmetric catalysis

A synthesis of new NeoPHOX ligands derived from serine or threonine has been developed. The central intermediate is a NeoPHOX derivative bearing a methoxycarbonyl group at the stereogenic center next to the oxazoline N atom. The addition of methylmagnesium chloride leads to a tertiary alcohol, which...

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Bibliographic Details
Main Authors: Jaroslav Padevět, Marcus G. Schrems, Robin Scheil, Andreas Pfaltz
Format: Article
Language:English
Published: Beilstein-Institut 2016-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.12.114