The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ entry in platelets

The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ entry in platelets

IntroductionPlatelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important role in platelet activation, because many cellular processes depend on the level of intracellular Ca2+ ([Ca2+](i)), such as integrin activat...

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Bibliographic Details
Main Authors: Friedrich Reusswig, Münteha Yilmaz, Marius Brechtenkamp, Irena Krueger, Lisa Maria Metz, Nikolaj Klöcker, Eckhard Lammert, Margitta Elvers
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
platelets
NMDAR
integrin
ATP
thrombosis
calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1171831/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1171831/full

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