HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.

Hypoxia-inducible factor 1 (HIF-1) mediates many of the systemic and cellular responses to intermittent hypoxia (IH), which is an experimental model that simulates O2 saturation profiles occurring with recurrent apnea. IH-evoked HIF-1α synthesis and stability are due to increased reactive oxygen spe...

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Bibliographic Details
Main Authors: Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A Khan, Ning Wang, Vladislav Makarenko, Gregg L Semenza, Nanduri R Prabhakar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119762

Internet

https://doi.org/10.1371/journal.pone.0119762

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