Deep learning enables reference-free isotropic super-resolution for volumetric fluorescence microscopy

Volumetric fluorescence microscopy is often limited by anisotropic spatial resolution. Here, the authors present an unsupervised deep-learning approach that enhances axial resolution by learning from high-resolution lateral images, and demonstrate isotropic resolution and restoration of suppressed v...

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Bibliographic Details
Main Authors: Hyoungjun Park, Myeongsu Na, Bumju Kim, Soohyun Park, Ki Hean Kim, Sunghoe Chang, Jong Chul Ye
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30949-6