Deep learning enables reference-free isotropic super-resolution for volumetric fluorescence microscopy
Volumetric fluorescence microscopy is often limited by anisotropic spatial resolution. Here, the authors present an unsupervised deep-learning approach that enhances axial resolution by learning from high-resolution lateral images, and demonstrate isotropic resolution and restoration of suppressed v...
Main Authors: | Hyoungjun Park, Myeongsu Na, Bumju Kim, Soohyun Park, Ki Hean Kim, Sunghoe Chang, Jong Chul Ye |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30949-6 |
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