Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

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Discrimination between hematopoietic stem cells and leukemic stem cells remains a major challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 antigen can deplete malignant and healthy hematopoietic stem cells before consolidation with allogeneic hematopoietic stem ce...

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Bibliographic Details
Main Authors: Chiara F. Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Laura Volta, Francesco Manfredi, Christian Pellegrino, Steve Pascolo, Csaba Miskey, Zoltán Ivics, Judith A. Shizuru, Dario Neri, Markus G. Manz
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
Chimeric antigen receptor
CAR
non-viral gene transfer
acute myeloid leukemia
cancer immunotherapy
hematopoietic stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000499

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http://www.sciencedirect.com/science/article/pii/S2372770523000499

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