Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines

Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines

Background: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein (Pgp), which recognizes and extrudes various chemotherapeutics from cancer...

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Bibliographic Details
Main Authors: Edina Karai, Kornélia Szebényi, Tímea Windt, Sára Fehér, Eszter Szendi, Valéria Dékay, Péter Vajdovich, Gergely Szakács, András Füredi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
lymphoma
multidrug resistance
P-glycoprotein
drug holiday
COX-2 inhibitors
celecoxib
Online Access:https://www.mdpi.com/2072-6694/12/5/1117

Internet

https://www.mdpi.com/2072-6694/12/5/1117

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