Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer’s disease

Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer’s disease

Intraneuronal accumulation of amyloid β (iAβ) has been linked to mild cognitive impairment that may precede Alzheimer’s disease (AD) onset. This neuropathological trait was recently mimicked in a novel animal model of AD, the hemizygous transgenic McGill-R-Thy1-APP (Tg+/-) rat. The characterization...

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Bibliographic Details
Main Authors: Pablo eGaleano, Pamela V. Martino Adami, Sonia eDo Carmo, Eduardo eBlanco, Cecilia eRotondaro, Francisco eCapani, Eduardo Miguel Castaño, A. Claudio Cuello, Laura eMorelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Alzheimer’s disease
cognitive impairment
amyloid β
transgenic rat models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00321/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00321/full

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