PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity

PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity

Chronic fluoride exposure can cause developmental neurotoxicity, however the precise mechanisms remain unclear. To explore the mechanism of mitophagy in fluoride-induced developmental neurotoxicity, specifically focusing on PRKAA1 in regulating the PINK1/Parkin pathway, we established a Sprage Dawle...

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Bibliographic Details
Main Authors: Yanling Tang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Panpan Xu, Yue Ma, Hengrui Xing, Qiang Niu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Fluoride
Developmental neurotoxicity
Aberrant mitophagy
PRKAA1
Autophagic degradation
Neuronal apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323002762

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http://www.sciencedirect.com/science/article/pii/S0147651323002762

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