kLa based scale-up cultivation of the extremophilic archaeon Sulfolobus acidocaldarius: from benchtop to pilot scale

kLa based scale-up cultivation of the extremophilic archaeon Sulfolobus acidocaldarius: from benchtop to pilot scale

The two major scale-up criteria in continuously stirred bioreactors are 1) constant aerated power input per volume (Pg/Vl), and 2) the volumetric O2 mass transfer coefficient (kla). However, Pg/Vl is only influenced by the stirrer geometry, stirrer speed, aeration and working volume, while the kla i...

Full description

Bibliographic Details
Main Authors: Kerstin Rastädter, David J. Wurm, Oliver Spadiut, Julian Quehenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioreactor scale-up
Sulfolobus acidocaldarius
kLa
mass transfer coefficient
continuous cultivation
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1160012/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1160012/full

Similar Items