Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia

Human hepatocellular carcinoma HepG2 cells are forced to oxidative phosphorylation (OXPHOS), when cultured in aglycemic conditions at galactose and glutamine. These Oxphos cells represent a prototype of cancer cell bioenergetics with mixed aerobic glycolysis and OXPHOS. We aimed to determine fractio...

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Bibliographic Details
Main Authors: Jan Ježek, Lydie Plecitá-Hlavatá, Petr Ježek
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
cancer mitochondria
HepG2 cells
hypoxia
glutaminolysis
aminotransferase inhibiton
Warburg phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00637/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00637/full

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