Compatibility and stability of ademetionine 1,4-butanedisulfonate injection mixed with fructose and glucose diluents and pilot study of long-term storage impurities by LC-MS/MS

Compatibility and stability of ademetionine 1,4-butanedisulfonate injection mixed with fructose and glucose diluents and pilot study of long-term storage impurities by LC-MS/MS

Abstract Fructose injection is occasionally used to dilute ademetionine 1,4-butanedisulfonate injection for patients who cannot receive glucose or sodium chloride injections in clinical settings. Since our PIVAS staff reported that discoloration occurred after ademetionine 1,4-butanedisulfonate diss...

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Bibliographic Details
Main Authors: Zhenxia Hu, Yin Xu, Jia Li, Yujie Gong, Rong Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Ademetionine
Fructose
Compatible stability
High-performance liquid chromatography
Liquid chromatography-tandem mass spectrometry
Online Access:https://doi.org/10.1038/s41598-024-75392-3

Internet

https://doi.org/10.1038/s41598-024-75392-3

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