LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis

LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis

Abstract Background Lysophosphatidic acid (LPA) is a pleiotropic lipid messenger that addresses at least six specific G-protein coupled receptors. Accumulating evidence indicates a significant involvement of LPA in immune cell regulation as well as Schwann cell physiology, with potential relevance f...

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Bibliographic Details
Main Authors: Fabian Szepanowski, Maximilian Winkelhausen, Rebecca D. Steubing, Anne K. Mausberg, Christoph Kleinschnitz, Mark Stettner
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Neuroinflammation
Subjects:
Lysophosphatidic acid (LPA)
Experimental autoimmune neuritis (EAN)
Inflammatory neuropathy
Guillain–Barré-syndrome
Schwann cell
Differentiation
Online Access:https://doi.org/10.1186/s12974-021-02350-5

Internet

https://doi.org/10.1186/s12974-021-02350-5

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