Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR

Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR

This study aims at analyzing the impact of the pharmacological inhibition of DNA damage response (DDR) targets (DNA-PK and ATR) on radiosensitization of bladder cancer cell lines of different molecular/histological subtypes. Applying DNA-PK (AZD7648) and ATR (Ceralasertib) inhibitors on SCaBER, J82...

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Bibliographic Details
Main Authors: Ahmed Ali Chughtai, Julia Pannhausen, Pia Dinger, Julia Wirtz, Ruth Knüchel, Nadine T. Gaisa, Michael J. Eble, Michael Rose
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
bladder cancer
DNA-PK
ATR
AZD7648
Ceralasertib
targeted therapy
Online Access:https://www.mdpi.com/2227-9059/10/6/1277

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https://www.mdpi.com/2227-9059/10/6/1277

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