Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review
IntroductionThere exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1288804/full |
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| author | Cristian Sandoval Cristian Sandoval Cristian Sandoval Karen Nahuelqueo Luciana Mella Blanca Recabarren Vanessa Souza-Mello Jorge Farías |
| author_facet | Cristian Sandoval Cristian Sandoval Cristian Sandoval Karen Nahuelqueo Luciana Mella Blanca Recabarren Vanessa Souza-Mello Jorge Farías |
| author_sort | Cristian Sandoval |
| collection | DOAJ |
| description | IntroductionThere exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, have been identified as potential preventive nutrients against the cardiometabolic hazards that are commonly associated with obesity. The objective of this comprehensive review was to elucidate the involvement of long-chain polyunsaturated fatty acids, specifically eicosapentaenoic acid and docosahexaenoic acid, in the modulation of gene expression during the progression of obesity.MethodsThe present analysis focused on primary studies that investigated the association between long-chain polyunsaturated fatty acids, gene expression, and obesity in individuals aged 18 to 65 years. Furthermore, a comprehensive search was conducted on many databases until August 2023 to identify English-language scholarly articles utilizing MeSH terms and textual content pertaining to long-chain polyunsaturated fatty acids, gene expression, obesity, and omega-3. The protocol has been registered on PROSPERO under the registration number CRD42022298395. A comprehensive analysis was conducted on a total of nine primary research articles. All research collected and presented quantitative data.Results and DiscussionThe findings of our study indicate that the incorporation of eicosapentaenoic and docosahexaenoic acid may have potential advantages and efficacy in addressing noncommunicable diseases, including obesity. This can be attributed to their anti-inflammatory properties and their ability to regulate genes associated with obesity, such as PPARγ and those within the ALOX family.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022298395, CRD42022298395. |
| first_indexed | 2024-03-11T10:58:46Z |
| format | Article |
| id | doaj.art-fb77a0f4cd794c8a962cf4fc2c9027fa |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T10:58:46Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-fb77a0f4cd794c8a962cf4fc2c9027fa2023-11-13T03:19:46ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12888041288804Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic reviewCristian Sandoval0Cristian Sandoval1Cristian Sandoval2Karen Nahuelqueo3Luciana Mella4Blanca Recabarren5Vanessa Souza-Mello6Jorge Farías7Escuela de Tecnología Médica, Facultad de Salud, Universidad Santo Tomás, Osorno, ChileDepartamento de Ingeniería Química, Facultad de Ingeniería y Ciencias, Universidad de La Frontera, Temuco, ChileDepartamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileCarrera de Tecnología Médica, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileCarrera de Tecnología Médica, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileCarrera de Tecnología Médica, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileLaboratorio de Morfometría, Metabolismo y Enfermedades Cardiovasculares, Centro Biomédico, Instituto de Biología, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, BrazilDepartamento de Ingeniería Química, Facultad de Ingeniería y Ciencias, Universidad de La Frontera, Temuco, ChileIntroductionThere exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, have been identified as potential preventive nutrients against the cardiometabolic hazards that are commonly associated with obesity. The objective of this comprehensive review was to elucidate the involvement of long-chain polyunsaturated fatty acids, specifically eicosapentaenoic acid and docosahexaenoic acid, in the modulation of gene expression during the progression of obesity.MethodsThe present analysis focused on primary studies that investigated the association between long-chain polyunsaturated fatty acids, gene expression, and obesity in individuals aged 18 to 65 years. Furthermore, a comprehensive search was conducted on many databases until August 2023 to identify English-language scholarly articles utilizing MeSH terms and textual content pertaining to long-chain polyunsaturated fatty acids, gene expression, obesity, and omega-3. The protocol has been registered on PROSPERO under the registration number CRD42022298395. A comprehensive analysis was conducted on a total of nine primary research articles. All research collected and presented quantitative data.Results and DiscussionThe findings of our study indicate that the incorporation of eicosapentaenoic and docosahexaenoic acid may have potential advantages and efficacy in addressing noncommunicable diseases, including obesity. This can be attributed to their anti-inflammatory properties and their ability to regulate genes associated with obesity, such as PPARγ and those within the ALOX family.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022298395, CRD42022298395.https://www.frontiersin.org/articles/10.3389/fnut.2023.1288804/fullgene expressionnutrigenomicsomega-3epigeneticsmolecular biology |
| spellingShingle | Cristian Sandoval Cristian Sandoval Cristian Sandoval Karen Nahuelqueo Luciana Mella Blanca Recabarren Vanessa Souza-Mello Jorge Farías Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review Frontiers in Nutrition gene expression nutrigenomics omega-3 epigenetics molecular biology |
| title | Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review |
| title_full | Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review |
| title_fullStr | Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review |
| title_full_unstemmed | Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review |
| title_short | Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review |
| title_sort | role of long chain polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic in the regulation of gene expression during the development of obesity a systematic review |
| topic | gene expression nutrigenomics omega-3 epigenetics molecular biology |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1288804/full |
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