Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5)

Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5)

<p>Abstract</p> <p>Background</p> <p>Functional inactivation of the tumor suppressor Smad4 in colorectal and pancreatic carcinogenesis occurs coincident with the transition to invasive growth. Breaking the basement membrane (BM) barrier, a prerequisite for invasive grow...

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Bibliographic Details
Main Authors: Hahn Stephan A, Schöneck Anna, Hoppe Sabine, Zapatka Marc, Böckmann Miriam, Zboralski Dirk, Schmiegel Wolff, Schwarte-Waldhoff Irmgard
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/215

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http://www.biomedcentral.com/1471-2407/8/215

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