Optimization and Validation of Dosage Regimen for Ceftiofur against <i>Pasteurella multocida</i> in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model

Optimization and Validation of Dosage Regimen for Ceftiofur against <i>Pasteurella multocida</i> in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model

Model informed drug development is a valuable tool for drug development and clinical application due to its ability to integrate variability and uncertainty of data. This study aimed to determine an optimal dosage of ceftiofur against <i>P. multocida</i> by ex vivo pharmacokinetic/pharma...

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Bibliographic Details
Main Authors: Kun Mi, Shanju Pu, Yixuan Hou, Lei Sun, Kaixiang Zhou, Wenjin Ma, Xiangyue Xu, Meixia Huo, Zhenli Liu, Changqing Xie, Wei Qu, Lingli Huang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
ceftiofur
<i>Pasteurella multocida</i>
PBPK/PD model
dosage regimen
mathematical model
Online Access:https://www.mdpi.com/1422-0067/23/7/3722

Internet

https://www.mdpi.com/1422-0067/23/7/3722

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