A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress

A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress

Objective: Due to the complexity and heterogeneity of osteoarthritis (OA) pathophysiology, studying the interaction between intrinsic molecular changes in chondrocytes after hyper-physiological mechanical stress (MS) and aberrant signalling of OA risk genes remains a challenge. In this study we set...

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Bibliographic Details
Main Authors: Ritchie G.M. Timmermans, Niek G.C. Bloks, Margo Tuerlings, Marcella van Hoolwerff, Rob G.H.H. Nelissen, Robert J.P. van der Wal, Peter M. van der Kraan, Arjen B. Blom, Martijn H.J. van den Bosch, Yolande F.M. Ramos, Ingrid Meulenbelt
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Mechanical stress
Human neo-cartilage
Osteoarthritis
OA risk genes
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000947

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http://www.sciencedirect.com/science/article/pii/S2665913121000947

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