Sample size estimation and re-estimation of cluster randomized controlled trials for real-time feedback, debriefing, and retraining system of cardiopulmonary resuscitation for out-of-hospital cardiac arrests

Background: In cluster randomized controlled trials (RCTs) for emergency medical services (EMS) system, we encounter the situation that the actual cluster size and ratio of allocated patients between two groups eventually differ from those used for sample size estimation because of the nature of pat...

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Bibliographic Details
Main Authors: Akiko Kada, Akihiro Hirakawa, Fumie Kinoshita, Yumiko Kobayashi, Toshihiro Hatakeyama, Daisuke Kobayashi, Chika Nishiyama, Taku Iwami
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865418301376