Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations

Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations

Abstract Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal...

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Bibliographic Details
Main Authors: Zhanping Shi, Yanan Geng, Jiping Liu, Huina Zhang, Liqiang Zhou, Quan Lin, Juehua Yu, Kunshan Zhang, Jie Liu, Xinpei Gao, Chunxue Zhang, Yinan Yao, Chong Zhang, Yi E. Sun
Format: Article
Language:English
Published: Oxford University Press 2017-07-01
Series:Protein & Cell
Subjects:
NSC/NPCs
SEZ/SVZ
single cell transcriptome
aging
cell cycle
Erk1/2
Online Access:http://link.springer.com/article/10.1007/s13238-017-0450-2

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http://link.springer.com/article/10.1007/s13238-017-0450-2

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