Diminished Expression of P-glycoprotein Using Focused Ultrasound Is Associated With JNK-Dependent Signaling Pathway in Cerebral Blood Vessels

Diminished Expression of P-glycoprotein Using Focused Ultrasound Is Associated With JNK-Dependent Signaling Pathway in Cerebral Blood Vessels

MRI-guided focused ultrasound (MRgFUS) combined with microbubbles (MBs) is a promising technology that can facilitate drug delivery through a temporarily disrupted blood-brain barrier (BBB) and induce the down-regulation of P-glycoprotein (P-gp) expression on the blood vessels. Despite the increasin...

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Bibliographic Details
Main Authors: HyoJin Choi, Eun-Hee Lee, Mun Han, Sang-Hyun An, Juyoung Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
blood-brain barrier
focused ultrasound
P-glycoprotein
c-Jun N-terminal kinase signaling
vessel integrity
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01350/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01350/full

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