Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy regulation

Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy regulation

Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs) demonstrated a significant therapeutic effect in the treatment of restenosis by the paracrine function of extracellular vesicles (EVs). However, the risk of tumorigenicity and poor cell survival limits its clinical applic...

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Bibliographic Details
Main Authors: Yecheng He, Quanfu Li, Feng Feng, Rupan Gao, Huadong Li, Yuxin Chu, Shaobo Li, Yin Wang, Ruoying Mao, Zhongzhong Ji, Yutao Hua, Jun Shen, Ziao Wang, Meng Zhao, Qing Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
arterial restenosis
hiPSC-EC
autophagy
extracellular vesicles
miR-126
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.922790/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.922790/full

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