RELAx – REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial

RELAx – REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial

Abstract Background Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of...

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Bibliographic Details
Main Authors: Anna Geke Algera, Luigi Pisani, Dennis C. J. Bergmans, Sylvia den Boer, Corianne A. J. de Borgie, Frank H. Bosch, Karina Bruin, Thomas G. Cherpanath, Rogier M. Determann, Arjen M. Dondorp, Dave A. Dongelmans, Henrik Endeman, Jasper J. Haringman, Janneke Horn, Nicole P. Juffermans, David M. van Meenen, Nardo J. van der Meer, Maruschka P. Merkus, Hazra S. Moeniralam, Ilse Purmer, Pieter Roel Tuinman, Mathilde Slabbekoorn, Peter E. Spronk, Alexander P. J. Vlaar, Marcelo Gama de Abreu, Paolo Pelosi, Ary Serpa Neto, Marcus J. Schultz, Frederique Paulus, for the RELAx Investigators and the PROVE Network Investigators
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Trials
Subjects:
Artificial ventilation
Invasive ventilation
Mechanical ventilation
Positive end-expiratory pressure
PEEP
Non-injured lungs
Online Access:http://link.springer.com/article/10.1186/s13063-018-2640-5

Internet

http://link.springer.com/article/10.1186/s13063-018-2640-5

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