Potential Ameliorating Role of Spironolactone in Trastuzumab-induced Cardiotoxicity: A Narrative Review

Potential Ameliorating Role of Spironolactone in Trastuzumab-induced Cardiotoxicity: A Narrative Review

Background: Around 20% of breast cancers (BCs) overexpress Human Epidermal Growth Factor Receptor 2 (HER-2). HER-2 overexpression is associated with increased tumor aggressiveness and poor prognosis. Trastuzumab (an anti-HER2 monoclonal antibody) has been reported to improve overall survival in earl...

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Bibliographic Details
Main Authors: Amir Ghabousian, Azin Alizadehasl, Niloufar Ansari, Mehrdad Haghazali
Format: Article
Language:English
Published: Shaheed Beheshti University of Medical Sciences 2021-11-01
Series:International Journal of Medical Toxicology and Forensic Medicine
Subjects:
spironolactone
trastuzumab
cardiotoxicity
heart failure
cardio-oncology
chemotherapy
mitochondria
oxidative stress
Online Access:https://journals.sbmu.ac.ir/ijmtfm/article/view/36127

Internet

https://journals.sbmu.ac.ir/ijmtfm/article/view/36127

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