A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure.

Children with obesity typically have larger left ventricular heart dimensions during adulthood. However, whether this is due to a persistent effect of adiposity extending into adulthood is challenging to disentangle due to confounding factors throughout the lifecourse. We conducted a multivariable m...

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Bibliographic Details
Main Authors: Katie O'Nunain, Chloe Park, Helena Urquijo, Genevieve M Leyden, Alun D Hughes, George Davey Smith, Tom G Richardson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001656