In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis

In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis

The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity. We sought to test the potential of phospholipid vesic...

Full description

Bibliographic Details
Main Authors: Lucía Román-Álamo, Mohamad Allaw, Yunuen Avalos-Padilla, Maria Letizia Manca, Maria Manconi, Federica Fulgheri, Jorge Fernández-Lajo, Luis Rivas, José Antonio Vázquez, José Esteban Peris, Xavier Roca-Geronès, Srisupaph Poonlaphdecha, Maria Magdalena Alcover, Roser Fisa, Cristina Riera, Xavier Fernàndez-Busquets
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
<i>Leishmania infantum</i>
<i>Leishmania pifanoi</i>
leishmaniasis
pentamidine
liposomes
drug encapsulation
Online Access:https://www.mdpi.com/1999-4923/15/4/1163

Internet

https://www.mdpi.com/1999-4923/15/4/1163

Similar Items