Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the dynamics of IS formation at the cell population level, the p...

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Bibliographic Details
Main Authors: Can Liu, Jiawei Zhou, Stephan Kudlacek, Timothy Qi, Tyler Dunlap, Yanguang Cao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
systems pharmacology
pharmacodynamics
immunotherapy
bispecific T cell engager
tumor resistance
immunological synapse
Online Access:https://elifesciences.org/articles/83659

Internet

https://elifesciences.org/articles/83659

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