Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells
The immune system of centenarians remains active and young to prevent cancer and infections. Aging is associated with inflammaging, a persistent low-grade inflammatory state in which CD4+ T cells play a role. However, there are few studies that have been done on the CD4+ T cell subsets in centenaria...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.877709/full |
| _version_ | 1817978369040449536 |
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| author | Lixing Zhou Meiling Ge Yan Zhang Xiaochu Wu Mi Leng Chunmei Gan Yi Mou Jiao Zhou Jiao Zhou C Alexander Valencia C Alexander Valencia C Alexander Valencia Qiukui Hao Bin Zhu Biao Dong Biao Dong Birong Dong |
| author_facet | Lixing Zhou Meiling Ge Yan Zhang Xiaochu Wu Mi Leng Chunmei Gan Yi Mou Jiao Zhou Jiao Zhou C Alexander Valencia C Alexander Valencia C Alexander Valencia Qiukui Hao Bin Zhu Biao Dong Biao Dong Birong Dong |
| author_sort | Lixing Zhou |
| collection | DOAJ |
| description | The immune system of centenarians remains active and young to prevent cancer and infections. Aging is associated with inflammaging, a persistent low-grade inflammatory state in which CD4+ T cells play a role. However, there are few studies that have been done on the CD4+ T cell subsets in centenarians. Herein, the changes in CD4+ T cell subsets were investigated in centenarians. It was found that with aging, the old adults had higher levels of proinflammatory cytokines and lower levels of anti-inflammatory cytokines in plasma. The levels of CRP, IL-12, TNF-α, IFN-γ, IL-6 and IL-10 were further increased in centenarians compared to old adults. While the levels of IL-17A, IL-1β, IL-23 and TGF-β in centenarians were closer to those in young adults. The total CD4+, CD8+, Th17 and Treg cells from peripheral blood mononuclear cells (PBMCs) were similar among the three groups. It was observed that the ratio of Th17/Treg cells was elevated in old adults compared to young adults. The ratio was not further elevated in centenarians but rather decreased. In addition, the ex vivo PBMCs differentiation assay showed that increased Th17 cells in centenarians tended to secrete fewer proinflammatory cytokines, while decreased Treg cells in centenarians were prone to secrete more anti-inflammatory cytokines. These observations suggested centenarians alleviated inflammaging by decreasing the ratio of Th17/Treg cells and changing them into anti-inflammatory secretory phenotypes, which provided a novel mechanism for anti-aging research. |
| first_indexed | 2024-04-13T22:28:17Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T22:28:17Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fb94ba1e356d444c95227f61b38e01152022-12-22T02:27:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.877709877709Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T CellsLixing Zhou0Meiling Ge1Yan Zhang2Xiaochu Wu3Mi Leng4Chunmei Gan5Yi Mou6Jiao Zhou7Jiao Zhou8C Alexander Valencia9C Alexander Valencia10C Alexander Valencia11Qiukui Hao12Bin Zhu13Biao Dong14Biao Dong15Birong Dong16National Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaGeroscience and Chronic Disease Department, The 8th Municipal Hospital for the People, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaInterpath Laboratory, Pendleton, OR, United StatesDepartment of Preclinical Education, Lake Erie College of Osteopathic Medicine, Erie, PA, United StatesNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaGeroscience and Chronic Disease Department, The 8th Municipal Hospital for the People, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaThe immune system of centenarians remains active and young to prevent cancer and infections. Aging is associated with inflammaging, a persistent low-grade inflammatory state in which CD4+ T cells play a role. However, there are few studies that have been done on the CD4+ T cell subsets in centenarians. Herein, the changes in CD4+ T cell subsets were investigated in centenarians. It was found that with aging, the old adults had higher levels of proinflammatory cytokines and lower levels of anti-inflammatory cytokines in plasma. The levels of CRP, IL-12, TNF-α, IFN-γ, IL-6 and IL-10 were further increased in centenarians compared to old adults. While the levels of IL-17A, IL-1β, IL-23 and TGF-β in centenarians were closer to those in young adults. The total CD4+, CD8+, Th17 and Treg cells from peripheral blood mononuclear cells (PBMCs) were similar among the three groups. It was observed that the ratio of Th17/Treg cells was elevated in old adults compared to young adults. The ratio was not further elevated in centenarians but rather decreased. In addition, the ex vivo PBMCs differentiation assay showed that increased Th17 cells in centenarians tended to secrete fewer proinflammatory cytokines, while decreased Treg cells in centenarians were prone to secrete more anti-inflammatory cytokines. These observations suggested centenarians alleviated inflammaging by decreasing the ratio of Th17/Treg cells and changing them into anti-inflammatory secretory phenotypes, which provided a novel mechanism for anti-aging research.https://www.frontiersin.org/articles/10.3389/fphar.2022.877709/fullcentenariansinflammagingT helper 17 cellregulatory T cellaging |
| spellingShingle | Lixing Zhou Meiling Ge Yan Zhang Xiaochu Wu Mi Leng Chunmei Gan Yi Mou Jiao Zhou Jiao Zhou C Alexander Valencia C Alexander Valencia C Alexander Valencia Qiukui Hao Bin Zhu Biao Dong Biao Dong Birong Dong Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells Frontiers in Pharmacology centenarians inflammaging T helper 17 cell regulatory T cell aging |
| title | Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells |
| title_full | Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells |
| title_fullStr | Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells |
| title_full_unstemmed | Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells |
| title_short | Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells |
| title_sort | centenarians alleviate inflammaging by changing the ratio and secretory phenotypes of t helper 17 and regulatory t cells |
| topic | centenarians inflammaging T helper 17 cell regulatory T cell aging |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.877709/full |
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