Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes

Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes

Background: The volatile anaesthetic sevoflurane protects cardiac tissue from reoxygenation/reperfusion. Mitochondria play an essential role in conditioning. We aimed to investigate how sevoflurane and its primary metabolite hexafluoroisopropanol (HFIP) affect necrosis, apoptosis, and reactive oxyge...

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Bibliographic Details
Main Authors: Birgit Roth Z'graggen, Martin Urner, Beatrice Beck-Schimmer, Martin Schläpfer
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:BJA Open
Subjects:
hexafluoroisopropanol
hypoxia/reoxygenation injury
mitochondrial bioenergy measurements
mitochondrial membrane potential depolarisation
oxygen consumption rate
postconditioning
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609622001150

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http://www.sciencedirect.com/science/article/pii/S2772609622001150

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